Clomipramine (Anafranil) has been used for its inhibitory effect on ejaculation in the management of premature ejaculation. In some men with
very short latencies (less than 1 minute) continuous therapy with a low daily dose of clomipramine, typically 20 or 30 mg, may be more effective than taking 25 mg as required. Any benefits may relate
to its effect as a serotonin reuptake inhibitor; other antidepressants with serotonin reuptake inhibiting actions, such as fluoxetine and sertraline, have also been tried in this
condition